Gene
osbp
- ID
- ZDB-GENE-090312-18
- Name
- oxysterol binding protein
- Symbol
- osbp Nomenclature History
- Previous Names
-
- si:ch211-149g8.3
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable sterol binding activity. Predicted to act upstream of or within lipid transport. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Orthologous to human OSBP (oxysterol binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028186Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa38299 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko1043a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-osbp | China Zebrafish Resource Center (CZRC) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018494 | Oxysterol-binding protein, conserved site |
| Domain | IPR001849 | Pleckstrin homology domain |
| Family | IPR000648 | Oxysterol-binding protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR037239 | Oxysterol-binding protein superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Oxysterol-binding protein | Oxysterol-binding protein, conserved site | Oxysterol-binding protein superfamily | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q6T9 | InterPro | 751 | |||||
| UniProtKB:A0A8M9PIA9 | InterPro | 759 | |||||
| UniProtKB:A0A8M9PVP0 | InterPro | 805 | |||||
| UniProtKB:A0A8M9QCC1 | InterPro | 773 | |||||
| UniProtKB:F6P8R2 | InterPro | 760 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-149G8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001145585 (1) | 2488 nt | ||
| Genomic | GenBank:BX004781 (1) | 169991 nt | ||
| Polypeptide | UniProtKB:A0AB32TLT7 (1) | 832 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhou, Y., Wohlfahrt, G., Paavola, J., and Olkkonen, V.M. (2014) A vertebrate model for the study of lipid binding/transfer protein function: Conservation of OSBP-related proteins between zebrafish and human. Biochemical and Biophysical Research Communications. 446(3):675-80
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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